کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3084333 1581267 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neuronal Ceroid Lipofuscinosis and Associated Sleep Abnormalities
ترجمه فارسی عنوان
Ceroid Lipofuscinosis عصبی و اختلالات مرتبط با خواب
کلمات کلیدی
خوابیدن لیپوفوشینوز سروئید نورونی؛ تشنج؛ از دست دادن بینایی؛ سندرم پای بی قرار
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب تکاملی
چکیده انگلیسی

PurposeThe aims of this study were to evaluate sleep difficulties in children with neuronal ceroid lipofuscinosis and to determine the association between the sleep difficulties and the onset of seizures and loss of vision.MethodWe recruited individuals with a confirmed diagnosis of neuronal ceroid lipofuscinosis. We obtained information from the caregiver using the validated Children's Sleep Habits Questionnaire which is a sleep instrument for both behaviorally and medically based problems. Additional information was collected including onset of symptoms, treatment trials, and screen for restless leg syndrome symptoms.ResultsIn our cohort of 54 individuals, 96.3% had sleep scores consistent with a sleep disturbance. Sleep subscale analysis provided additional insight into the characteristics of the sleep disturbance. Fifty two of the 54 patients had at least one abnormal sleep subscale. The onset of sleep disturbance was associated with the onset of both seizures (ρ = 0.5834, P < 0.0001) and loss of vision (ρ = 0.3840, P = 0.0084). Restless leg syndrome symptoms were reported in 35.2%.ConclusionChildren with neuronal ceroid lipofuscinosis have a high burden of sleep disturbances. Using the results of a sleep disturbance screening tool can help to identify the most disturbing symptoms. Targeted treatment of sleep disturbance may improve the quality of life for the patient and family.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pediatric Neurology - Volume 59, June 2016, Pages 30–35
نویسندگان
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