کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3176448 1200269 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A preliminary study of slow-wave EEG activity and insulin sensitivity in adolescents
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
A preliminary study of slow-wave EEG activity and insulin sensitivity in adolescents
چکیده انگلیسی

ObjectiveThe objective was to evaluate the relationship between the time course of slow wave EEG activity (SWA) during NREM sleep and insulin sensitivity in adolescents.MethodsNine normal weight and nine overweight (BMI > 85th percentile) adolescents (13–18 years of age) participated. None of the participants had a history of sleep disordered breathing, confirmed by sleep study. Participants maintained a regularized sleep wake cycle for five days followed by overnight polysomnography in the lab or at home. An oral glucose tolerance test (OGTT) was administered after a 12 h fast and within two weeks of the sleep study. Whole body insulin sensitivity (WBISI) and homeostasis model assessment (HOMA-IR) determined insulin resistance. Power spectral analysis quantified slow-wave EEG activity (.05–3.9 Hz) and exponential regression evaluated SWA across successive NREM periods.ResultsThose who were insulin resistant and had low insulin sensitivity had less Stages 2, 3 and 4 of NREM sleep, more Stage 1, but did not sleep less than those with low resistance and high sensitivity. SWA power was significantly lower in the first NREM period and the decay rate of SWA across NREM sleep was significantly slower in the low insulin sensitivity group. Similar results were obtained after removing the influence of BMI and Tanner score.ConclusionsInsulin sensitivity in adolescents is related to SWA power and its time course, not total sleep time, regardless of BMI.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sleep Medicine - Volume 14, Issue 3, March 2013, Pages 257–260
نویسندگان
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