کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3261196 1207681 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Long interspersed nuclear element (LINE)-1 methylation level as a molecular marker of early gastric cancer
ترجمه فارسی عنوان
سطح متیلاسیون (LINE) -1 عنصر هسته ای آمیخته بلند به عنوان مارکر مولکولی از سرطان معده اولیه
کلمات کلیدی
سرطان معده؛ عنصر هسته ای بلند پراکنده (خطی). RUNX3
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
چکیده انگلیسی

Background/aimsThis study was performed to examine the state of long interspersed nuclear element (LINE)-1 methylation level in gastric epithelial dysplasias (GEDs) and evaluate as a molecular marker for gastric carcinogenesis when it was compared with RUNX3 expression.MethodsWe examined 89 patients with GEDs subcategorized by the Vienna classification – 41 category 3 (low grade) and 48 category 4 (high grade/intramucosal carcinoma) lesion. All tissue samples were evaluated for RUNX3 immunohistochemical staining and the level of LINE-1 methylation.ResultsThe rate of negative expression of RUNX3 in category 4 lesion was significant higher than category 3 (P < 0.01). LINE-1 methylation level was statistically different between category 3 and category 4 lesion (P < 0.01). Between positive and negative expression of RUNX3 in GEDs, there was a significant difference of LINE-1 methylation level (P < 0.01). The area under the ROC curve (AUC) of LINE-1 methylation level for diagnosis of category 4 lesion was 0.88 (95% CI, 0.76–1.00).ConclusionsLINE-1 methylation level was well correlated with the Vienna classification of GED and it had a close relationship with the negative expression of RUNX3 in category 4 lesion. LINE-1 methylation level could be a good candidate for a molecular marker of early gastric cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Digestive and Liver Disease - Volume 48, Issue 9, September 2016, Pages 1093–1097
نویسندگان
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