کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3261218 1207682 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Seronegative autoimmune hepatitis in children: Spectrum of disorders
ترجمه فارسی عنوان
هپاتیت سرم منفی خودایمنی در کودکان: طیفی از اختلالات
کلمات کلیدی
هپاتیت خودایمنی اتوآنتی بادی منفی ؛ نارسایی کبد؛ پیوند کبد؛ کم خونی آپلاستیک شدید
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
چکیده انگلیسی

BackgroundA few children with acute or chronic liver disease display histological features compatible with autoimmune hepatitis, but lack specific serological markers.AimTo describe features, management and outcome of childhood seronegative autoimmune hepatitis.MethodsFrom 1988 to 2010, 38 children were included under the following criteria: negative virological studies, no serum autoantibodies, exclusion of other causes of liver diseases, and liver histology compatible with autoimmune hepatitis.ResultsFour groups were identified: (1) 12 with increased serum gamma globulin concentrations; (2) 10 with normal or low serum gamma globulins and no combined blood disease; (3) 10 with combined aplastic anemia; and (4) 6 with peripheral thrombocytopenia with/without neutropenia. Immunosuppressive treatment was associated with aminotransferases normalization in all but one child who required liver transplantation. Relapses occurred in 10 children. Lymphocytopenia was found at the time of the diagnosis of hepatitis in 13 children, 12 in groups 3 or 4. All 38 children are alive after 4–17 years, 18 still under immunosuppression.ConclusionsChildhood seronegative autoimmune hepatitis includes a spectrum of disorders. Early liver histology is recommended and, if compatible with autoimmune hepatitis, immunosuppressive treatment should be started. Initial lymphocytopenia may indicate future hematological complication.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Digestive and Liver Disease - Volume 48, Issue 7, July 2016, Pages 785–791
نویسندگان
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