کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3345892 | 1591312 | 2014 | 6 صفحه PDF | دانلود رایگان |
• Much is unclear about protective CD4 T cell responses against Mycobacterium tuberculosis.
• Th1 responses are essential but other effector mechanisms also protect against Mtb.
• Vaccines that generate fewer terminally differentiated T cells are more protective.
• Mtb-specific CD4 T cells that rapidly enter the lung tissue are highly protective.
CD4 T cells are critical for control of Mycobacterium tuberculosis (Mtb) infection and represent the best hope for vaccine-elicited protection. However, little is understood about the properties of Mtb-specific CD4 T cells that mediate control, and the lack of correlates of protection present a significant barrier to the rational development of new vaccination and therapeutic strategies which are sorely needed. Here we discuss the features of protective CD4 T cells including recent evidence for IFN-γ dependent and independent mechanisms of protection, poor protection by terminally differentiated cells and the importance of T cell migratory capacity for the control of Mtb infection.
Journal: Current Opinion in Immunology - Volume 29, August 2014, Pages 137–142