کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
922077 921024 2016 5 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله
Evaluation of periodontitis in hospital outpatients with major depressive disorder. A focus on gingival and circulating cytokines
ترجمه فارسی عنوان
بررسی پریودنتیت در بیماران سرپایی بیمارستان با اختلال افسردگی اساسی. تمرکز بر لثه و سیتوکین گردش
کلمات کلیدی
اینترفرون γ؛ اینترلوکین 1β؛ اینترلوکین 6؛ اختلال افسردگی اساسی؛ بیماری پریودنتال
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی


• We observed modest immunosuppression in major depressive disorder (MDD) patients.
• The gingival crevicular fluid (GCF) IL-1β level was modestly reduced in MDD patients.
• There was no significant correlation between the levels of GCF cytokines and circulating cytokines.

An imbalance in stimulated cytokine production is associated with the etiopathogenesis of numerous diseases such as major depressive disorder (MDD) and periodontal disease. Increased cytokine levels have been reported in the gingival crevicular fluid (GCF) of patients with MDD. Thirty-six outpatients with MDD participated in this study. Each outpatient was age-matched (±3 years) with a healthy control (n = 36). The patients were controlled for race and smoking habits. Unstimulated and stimulated interleukin 6 (IL-6), interleukin 1β (IL-1β), and interferon-γ (INF-γ) production in whole blood culture (WBC) and IL-6 and IL-1β levels in the GCF were evaluated. Circulating levels of IL-6 and IL-1β (unstimulated) as well as GCF IL-1β were modestly lower in MDD patients, compared to the levels in age-matched controls (Mann–Whitney, p = 0.002, 0.0075, ANCOVA, p = 0.025, respectively). In the unstimulated group, there was no correlation between the levels of circulating IL-6 and GCF IL-6 (r = 0.07, p = 0.67), and between the levels of circulating IL-1β and the IL-1β level in the CGF (r = −0.08, p = 0.63). In the LPS stimulation group, there was no correlation between the levels of circulating levels of IL-6 and GCF IL-6 (r = 0. 02, p = 0.91) or between the circulating IL-1β and GCF IL-1β (r = 0.13, p = 0.42). We observed modest immunosuppression in MDD patients (evaluated by no stimulation whole blood culture [WBC]), especially in patients with melancholic depression, chronic depression, and severe depression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain, Behavior, and Immunity - Volume 53, March 2016, Pages 49–53
نویسندگان
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