Heterologous prime–boost vaccination

An effective vaccine usually requires more than one time immunization in the form of prime–boost. Traditionally the same vaccines are given multiple times as homologous boosts. New findings suggested that prime–boost can be done with different types of vaccines containing the same antigens. In many cases such heterologous prime–boost can be more immunogenic than homologous prime–boost. Heterologous prime–boost represents a new way of immunization and will stimulate better understanding on the immunological basis of vaccines.