کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3353213 | 1216844 | 2013 | 11 صفحه PDF | دانلود رایگان |
• Commensal but not pathogenic bacteria induce IFN-β secretion in small intestine
• LAB-induced IFN-β is beneficial in protection from infection and colitis
• TLR3 on intestinal DCs sense commensal bacteria dsRNA to produce IFN-β
• LAB can be utilized as probiotics to induce protective IFN-β from DCs
SummaryThe small intestine harbors a substantial number of commensal bacteria and is sporadically invaded by pathogens, but the response to these microorganisms is fundamentally different. We identified a discriminatory sensor by using Toll-like receptor 3 (TLR3). Double-stranded RNA (dsRNA) of one major commensal species, lactic acid bacteria (LAB), triggered interferon-β (IFN-β) production, which protected mice from experimental colitis. The LAB-induced IFN-β response was diminished by dsRNA digestion and treatment with endosomal inhibitors. Pathogenic bacteria contained less dsRNA and induced much less IFN-β than LAB, and dsRNA was not involved in pathogen-induced IFN-β induction. These results identify TLR3 as a sensor to small intestinal commensal bacteria and suggest that dsRNA in commensal bacteria contributes to anti-inflammatory and protective immune responses.
Graphical AbstractFigure optionsDownload high-quality image (329 K)Download as PowerPoint slide
Journal: - Volume 38, Issue 6, 27 June 2013, Pages 1187–1197