کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3353385 | 1216854 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Host Defense Pathways: Role of Redundancy and Compensation in Infectious Disease Phenotypes
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
Innate host defense pathways consist of microbial sensors, their signaling pathways, and the antimicrobial effector mechanisms. Several classes of host defense pathways are currently known, each comprising several pattern-recognition receptors that detect different types of pathogens. These pathways interact with one another in a variety of ways that can be categorized into cooperation, complementation, and compensation. Understanding the principles of these interactions is important for better understanding of host defense mechanisms, as well as for correct interpretation of immunodeficient phenotypes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 34, Issue 5, 27 May 2011, Pages 629–636
Journal: - Volume 34, Issue 5, 27 May 2011, Pages 629–636
نویسندگان
Simone Nish, Ruslan Medzhitov,