کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3353400 | 1216854 | 2011 | 13 صفحه PDF | دانلود رایگان |
SummaryInfection or vaccination confers heightened resistance to pathogen rechallenge because of quantitative and qualitative differences between naive and primary memory T cells. Herein, we show that secondary (boosted) memory CD8+ T cells were better than primary memory CD8+ T cells in controlling some, but not all acute infections with diverse pathogens. However, secondary memory CD8+ T cells were less efficient than an equal number of primary memory cells at preventing chronic LCMV infection and are more susceptible to functional exhaustion. Importantly, localization of memory CD8+ T cells within lymph nodes, which is reduced by antigen restimulation, was critical for both viral control in lymph nodes and for the sustained CD8+ T cell response required to prevent chronic LCMV infection. Thus, repeated antigen stimulation shapes memory CD8+ T cell populations to either enhance or decrease per cell protective immunity in a pathogen-specific manner, a concept of importance in vaccine design against specific diseases.
► Secondary (boosted) memory CD8+ T cells protect better against some acute infections
► Secondary memory CD8+ T cells are more “exhaustible” than primary memory cells
► Primary memory CD8+ T cells are better at preventing chronic LCMV infection
► Lymph node entry is critical for memory CD8+ T cell protection against chronic LCMV
Journal: - Volume 34, Issue 5, 27 May 2011, Pages 781–793