کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3354287 | 1216924 | 2006 | 11 صفحه PDF | دانلود رایگان |
SummaryThe immune system preserves and makes use of autoreactive lymphocytes with specialized functions. Here we showed that one of these populations, CD8αα+TCRαβ+ intestinal intraepithelial lymphocytes (IELs), arose from a unique subset of double-positive thymocytes. This subset of cells was precommitted to preferentially give rise to CD8αα+TCRαβ+ IELs, but they required exposure to self-agonist peptides. The agonist-selected TCRαβ+ thymocytes are CD4 and CD8 double-negative, and their final maturation, including the induction of CD8αα expression, appeared to occur only after thymus export in the IL-15-rich environment of the gut. These developmental steps, including precommitment of immature thymocytes, TCR-mediated agonist selection, and postthymic differentiation promoted by cytokines, define a unique pathway for the generation of CD8αα+TCRαβ+ IEL.
Journal: - Volume 25, Issue 4, October 2006, Pages 631–641