کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3355533 | 1217189 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The expression of human leukocyte antigen G (HLA-G) is associated with sacroiliitis stages of ankylosing spondylitis
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Recent studies have demonstrated that human leukocyte antigen G (HLA-G) may play an important role in autoimmune diseases. The present study is to investigate whether or not HLA-G is associated with sacroiliitis stages of ankylosing spondylitis (AS), a systemic autoimmune disease. Plasma levels of soluble HLA-G (sHLA-G) and HLA-G expression on the surface of peripheral blood mononuclear cells (PBMCs) were measured in 55 AS patients and 49 healthy controls by using a specific HLA-G ELISA and flow cytometric (FCM) analysis, respectively. Association of HLA-G expression with sacroiliitis stages of the patients was statistically analyzed. The plasma sHLA-G concentrations were noticeably lower in the AS patients when compared to the healthy controls while the mean fluorescence intensity (MFI) of the HLA-G expression on the surface of PBMCs was significantly higher in the AS patients than in the healthy controls (both PÂ <Â 0.0001). The HLA-G expression on the surface of PBMCs, plasma sHLA-G levels and HLA-B27 expression were significantly correlated to each other. Moreover, the plasma sHLA-G was inversely associated with the sacroiliitis stages (PÂ =Â 0.008), while the HLA-G expression on the surface of PBMCs increased from stage 0 to II but decreased in stage III (PÂ =Â 0.001). The significant association of HLA-G expressions with AS sacroiliitis stages suggests that HLA-G is possibly involved in the pathology of the disease. The detection of HLA-G expression may therefore be a useful laboratory test to reveal disease process in AS patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 152, Issue 2, May 2013, Pages 121-125
Journal: Immunology Letters - Volume 152, Issue 2, May 2013, Pages 121-125
نویسندگان
Jian-bo Zhang, Zhi-ying Wang, Jie Chen, Xiao-dan Wu, Bin Zhou, Shang-mian Yie,