کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3356201 | 1217243 | 2008 | 5 صفحه PDF | دانلود رایگان |
In mice CR1 and CR2 are encoded at a single locus and the two alternatively spliced RNA transcripts of the CD21 gene generate murine CR1 and CR2 (CR1/2). While the function of CD21 has been extensively studied on murine B lymphocytes, much less is known about its appearance and role on T cells. Earlier we had demonstrated the expression of CR1/2 on activated murine T cells by cytofluorymetry and immunoprecipitation and proposed its role in the enhancement of antigen presentation by B cells and macrophages bearing C3-fragments. In this study we analyze the expression-profile and further possible roles of CR1/2 on T lymphocytes. We describe a CR1/2 expressing CD4+ T cell subpopulation present in the mesenteric lymph nodes of mice. We show that these cells can be activated by the CD21-specific 7G6 single chain antibody, and demonstrate that activation via this complement receptor results in the translocation of NF-κB to the nucleus. Interestingly we found a substantial elevation of CD21+ T cells during both spontaneous and ceramide-induced apoptosis.
Journal: Immunology Letters - Volume 116, Issue 2, 15 March 2008, Pages 163–167