کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3358142 | 1217863 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
HLA-DPA1*/DPB1* en asociación con leucemias linfoides agudas y leucemias mieloides crónicas en mestizos venezolanos
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
More is now known of the involvement of HLA-DP region in the pathogenesis of the leukemias through several previousstudies showing interference of these molecules in modulating the immune response to pathogens. For evaluation of HLA alleles and haplotypes DPA1*/DPB1* (28 alleles HLA DPA1* and 123 of HLA- DPB1*) Olerup SSP â¢PCR (Genovision) was used in 48 patients with ALL, 48 CML, and 48 Venezuelan twins as controls. For HLA/leukemias, a relative risk (RR) > 3 was considered to be a positive association and negative with an RR < 3, with a p corrected P<.05. ALL patients confirmed positive associations with DPA1*0105 allele, and negative with DPA1*010301-010302. In addition, they were positively associated with DPA1*0106 and *0107, with DPA1*020101-020106 being negatively associated with ALL. DPA1*0105, *0108 and *0109 were negatively associated with CML. The observed frequencies of HLA-DPB1* 01:01, 02:01, 03:01, 04:01 and 4:02 alleles in Venezuelan, which twins were between 7 and 16%, were higher than those of leukemic patients. Negative associations of DPB1*2:01, *3:01 and LLA were confined. No positive associations were observed with ALL. Non-confirmed positive associations were observed between DPB1*99:01 and CML. Haplotypes HLA-DPA1*01:03-DPB1*4:01, *2:01, *99:01 were strongly positively associated with CML. DPA1*1:09-DPB1*2:01, *4:01 were negatively associated with the CML. DPA1*1:03-DPB1*4:02; DPA1*01:09-DPB1*2:01, *4:01 and DPA1*02:01-DPB1*04:02 were negatively associated with ALL. The DPB1* single region does not appear to be associated with leukemia in the Venezuelan population. The strong association with several haplotypes DPA*1/DPB1* and LMC suggests massive differences between the pathogenesis of both diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: InmunologÃa - Volume 33, Issue 3, JulyâSeptember 2014, Pages 81-86
Journal: InmunologÃa - Volume 33, Issue 3, JulyâSeptember 2014, Pages 81-86
نویسندگان
Sergio Rivera Pirela, Miriam EcheverrÃa, Georgina Márquez, Zuhey Carrillo, Yennis Parra, Pedro Salcedo, Melchor Álvarez de Mon Soto,