کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3362629 1592073 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Long-term outcomes of HIV-infected children in Thailand: the Thailand Pediatric HIV Observational Database
ترجمه فارسی عنوان
نتایج بلند مدت کودکان مبتلا به اچ آی وی در تایلند: بانک اطلاعات تندرستی اطفال
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
چکیده انگلیسی

SummaryObjectiveTo describe the outcomes of antiretroviral therapy (ART) in a large cohort of HIV-infected children in Thailand.MethodsThe data were obtained from four collaborative referral sites around the country. Data from 2008 to March 2011 were collected prospectively, and data before 2008 were collected retrospectively.ResultsOf the 1139 children, 599 (52.6%) were female, and the duration of ART was a median 2.9 years (interquartile range (IQR) 3.3–5.5 years). At ART initiation, the median age was 7.1 years (IQR 3.4–10.0 years), CD4 percentage was 9.0% (IQR 3.0–17.0%), and 61.3% were in World Health Organization (WHO) stage 3 or 4. Seventy-four percent were initiated on an NNRTI-based regimen. The death and lost to follow-up rates were 1.3 (95% confidence interval (CI) 1.1–1.6) and 2.2 (95% CI 1.6–2.6)/100 patient-years of follow-up, respectively. At the last clinic visit of 919 children, the median CD4 percentage was 27.0% (IQR 23.0–32.0%) and 80.2% had HIV-RNA <40 copies/ml. WHO stage 1 or 2 at ART initiation was associated with having a viral load <40 copies/ml (p < 0.002), and baseline CD4 ≥15% and starting with a three-drug regimen were associated with achieving CD4 ≥25% (p < 0.001).ConclusionsAlthough most children initiated ART at low CD4 levels, the majority achieved immune reconstitution and long-term virological control. Earlier treatment may improve these outcomes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Infectious Diseases - Volume 22, May 2014, Pages 19–24
نویسندگان
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