کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3365528 1218370 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sodium thiosulfate is effective in calcific uremic arteriolopathy complicating chronic hemodialysis
ترجمه فارسی عنوان
تيوسولفات سديم در آرتريولوپاتي اوره کلسيفيک با پیچیدگی همودياليز مزمن موثر است
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ایمونولوژی، آلرژی و روماتولوژی
چکیده انگلیسی

BackgroundCalcific uremic arteriolopathy (CUA) or calciphylaxis is a severe complication of advanced chronic kidney disease (CKD) and dialysis. Few effective treatments are available and the mortality rate is high. We report 4 cases in which sodium thiosulfate therapy was rapidly effective.CasesSodium thiosulfate therapy was given to 4 Caucasian patients (3 females and 1 male aged 49 to 91 years) with CUA. The causes of end-stage CKD were nephroangiosclerosis (n = 2) and diabetic nephropathy (n = 2). The lesions developed 1 to 6.5 years after the initiation of hemodialysis and involved the lower limbs in 2 patients, the fingers in 1 patient, and a breast in the remaining patient. They were responsible for pain and skin necrosis in all 4 patients. Local superinfection occurred in 3 patients. Intravenous sodium thiosulfate was given in a dosage of 12.5 to 25 g after each hemodialysis session, for 12 to 24 weeks. The pain and trophic disorders resolved fully in all 4 patients. The side effects consisted of nausea and vomiting (n = 2) and a moderate blood pressure decrease (n = 1). No recurrences were noted during the follow-up of 5 to 17 months after treatment discontinuation.ConclusionThe findings from this small case-series suggest that sodium thiosulfate may hold promise for the treatment of CUA.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Joint Bone Spine - Volume 83, Issue 1, January 2016, Pages 89–92
نویسندگان
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