کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3369955 | 1219060 | 2008 | 6 صفحه PDF | دانلود رایگان |
BackgroundAmong pre-adolescents, the importance of different sources of cytomegalovirus (CMV) infection is unclear.ObjectiveTo assess the importance of several CMV sources among pre-adolescent children.Study designWe used data from a United States population-based sample conducted from 1988 to 1994: 4–10-year-old participants (n = 3386) of the Third National Health and Nutrition Examination Survey. We tested available sera for CMV-specific-IgG and assessed CMV prevalence differences by surrogates for exposure to childhood CMV sources (maternal CMV serostatus, breast-feeding, older sibling CMV serostatus, and child care center attendance).ResultsCMV infection was more prevalent (70%) among Mexican American children with foreign-born householders than among children with native-born householders (31% non-Hispanic White, 39% non-Hispanic Black, and 37% Mexican American children). Child's serostatus was associated with their mother's (prevalence difference range (PDR) = 33–40%) and older sibling's serostatus (PDR = 39–50%). Breast-feeding was associated with CMV in some racial/ethnic and householder groups (PDR = −5.1% to 22.7%). There was little difference in CMV seroprevalence by child care center attendance (PDR = −6.5% to −0.4%).ConclusionsThis study expands understanding of CMV by identifying the importance of householder nativity and demonstrating the importance of family transmission among the general population of pre-adolescents.
Journal: Journal of Clinical Virology - Volume 43, Issue 3, November 2008, Pages 266–271