کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3373595 1219302 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Efficacy of oral chlorhexidine in preventing lower respiratory tract infections. Meta-analysis of randomized controlled trials
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Efficacy of oral chlorhexidine in preventing lower respiratory tract infections. Meta-analysis of randomized controlled trials
چکیده انگلیسی

SummarySeveral randomized controlled trials (RCTs) have examined the influence of oral chlorhexidine (CHX) in preventing nosocomial lower respiratory tract infection (LRTI). Most have failed to demonstrate a reduction in the incidence of LRTI. The present meta-analysis summarizes the effect of oral CHX on the development of LRTI. RCTs were identified through searching PubMed, MEDLINE and the Cochrane Central Register of Controlled Trials databases. Those describing the use of chlorhexidine for oral decontamination and reporting the incidence of LRTI as a study outcome were included in the meta-analysis. Seven RCTs met the inclusion criteria; pooling the results from these reveals a reduction in the relative risk (RR) of LRTI in the CHX group [RRrandom: 0.58, 95% confidence interval (CI): 0.45–0.74; and RRfixed: 0.56, CI95: 0.44–0.72, respectively]. Further analyses showed that this result applied only to patients ventilated for up to 48 h (RRrandom: 0.58, CI95: 0.45–0.74; and RRfixed: 0.56, 95% CI: 0.44–0.72). Oral CHX should be included among preventive measures performed to reduce nosocomial LRTI. Whether it has an impact on the development of LRTI in patients requiring mechanical ventilation for a longer period of time remains unresolved.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hospital Infection - Volume 66, Issue 3, July 2007, Pages 207–216
نویسندگان
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