کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3376671 1219920 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Decreased serum bone specific alkaline phosphatase and increased urinary N-terminal telopeptide of type I collagen as prognostic markers for bone mineral density loss in HIV patients on cART
ترجمه فارسی عنوان
فسفاتاز کاهش یافته آلکالین سرم خاص استخوان و telopeptide ترمینال N ادرار افزایش یافته از کلاژن نوع یک به عنوان مارکرهای پیش آگهی برای از دست دادن تراکم معدنی استخوان در بیماران مبتلا به HIV در cART
کلمات کلیدی
فسفاتاز استخوان های قلیایی خاص (BAP)؛ کلوپپتید N-terminal ادراری کلاژن نوع I (NTx)؛ اچ آی وی؛ تراکم معدنی استخوان (BMD)
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
چکیده انگلیسی

ObjectivesBone mineral density (BMD) loss is a major chronic complication in HIV patients. We performed a prospective study to determine the time course of BMD changes and to find prognostic factors of BMD loss in HIV patients on combination antiretroviral therapy (cART).Patients and methodsSubjects were 54 male Japanese HIV patients who had been on cART ≥1 year with no therapeutic agents for osteoporosis. Patients were observed for ≥1 year (median 3.1 years) and underwent annual BMD analyses using dual energy X-ray absorptiometry. Changes in BMD at lumbar spine and femoral neck were calculated for each person-year of all the patients. Clinical factors were also collected simultaneously with BMD examinations to determine prognostic factors for BMD loss.ResultsIn total, 173 person-years in 54 patients were observed. One third (19, 35.2%) and slightly over half (30, 55.6%) patients showed BMD decreases at lumbar spine and femoral neck, respectively. However, the median BMD changes at lumbar spine and femoral neck were 0.0% and −0.52% per year, respectively. Monovariant and mixed model analyses determined that decreased serum bone specific alkaline phosphatase (BAP, p = 0.0047) and increased urinary N-terminal telopeptide (uNTx, p = 0.0011) were prognostic factors for BMD loss at lumbar spine and femoral neck, respectively.ConclusionsBMD at both lumbar spine and femoral neck changed little on average in HIV patients on cART. Decreased serum BAP or increased uNTx may be helpful to predict progressive BMD loss in the following year and to select patients for BMD follow-up or initiation of anti-osteoporosis treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Infection and Chemotherapy - Volume 22, Issue 8, August 2016, Pages 543–547
نویسندگان
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