کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3392654 | 1221232 | 2006 | 4 صفحه PDF | دانلود رایگان |
The presence of MICA antibodies was examined in eleven patients diagnosed with AHR. MICA typing was performed in both recipients and donors. Sera were collected sequentially: pre-transplant, at the AHR episode and at follow-up. Sera from 30 patients with functioning graft were also analysed. A stable MICA⁎008 transfected cell line was used as target to identify MICA antibodies.MICA antibodies were not detected pre-transplant nor post-transplant in patients receiving a compatible graft. MICA antibodies were detected post-transplant AHR in patients receiving an incompatible graft. The persistence of MICA antibodies was associated with chronic graft dysfunction in 3 of 4 patients in this series; although it was not always associated with the graft loss in treated AHR.None of the 30 patients in the control group with long-term functioning grafts showed antibodies to MICA⁎008.This report provides some insights of the relevance of MICA antibodies in AHR.
Journal: Transplant Immunology - Volume 17, Issue 1, December 2006, Pages 39–42