Association study of the gamma-aminobutyric acid type a receptor γ2 subunit gene with schizophrenia

Schizophrenia (SCZ) is a severe neuropsychiatric disorder with a strong genetic basis. We analyzed eight GABRG2 and one DRD5 tag single-nucleotide polymorphisms for association with SCZ in 109 small nuclear families and 229 independent SCZ case-control pairs. The marker rs183294 in the 5′ region of GABRG2 was found to be associated with SCZ in both samples with the C allele over-represented in SCZ cases and over-transmitted in SCZ families (combined z = 9.18; p < 1 × 10− 3). Taken together, the results of the present study suggest that GABRG2 may be involved in SCZ susceptibility, but further studies are required.