کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3443893 1595244 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genetic polymorphisms in DNA repair and oxidative stress pathways may modify the association between body size and postmenopausal breast cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Genetic polymorphisms in DNA repair and oxidative stress pathways may modify the association between body size and postmenopausal breast cancer
چکیده انگلیسی

PurposeObesity is associated with increased bioavailability of estrogen, hyperinsulinemia, and chronic inflammation, all of which may promote tumor growth. Given DNA repair and oxidative stress pathways may work together with these mechanisms to influence carcinogenesis, we hypothesized that genetic variation in these pathways may modify the obesity-postmenopausal breast cancer (BC) association.MethodsResources from a population-based case-control study (990 cases and 970 controls) were used to construct logistic regression models. Body mass index (BMI, weight [kilogram]/height [square meter]) was assessed 1 year before reference date. We characterized interactions between BMI and 29 genetic polymorphisms in oxidative stress and DNA repair pathways.ResultsAge-adjusted odds ratios (95% confidence intervals) for postmenopausal BC were 1.24 (1.00–1.52) and 1.35 (1.09–1.71) for 25 ≥ BMI < 30 and BMI ≥ 30 kg/m2, respectively. We observed multiplicative interactions (P ≤ .05) for eight gene polymorphisms in DNA repair and oxidative stress pathways. For example, among MPO variant allele carriers, obesity was associated with a twofold increased risk of postmenopausal BC (2.13 [1.35–3.36]); however, in wild-type homozygotes, the relationship was less pronounced (1.33 [0.93–1.89]). Our findings were no longer significant after Bonferroni correction.ConclusionsObesity may be particularly deleterious for postmenopausal BC development in the presence of biologically plausible DNA repair or oxidative stress genotypes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Annals of Epidemiology - Volume 25, Issue 4, April 2015, Pages 263–269
نویسندگان
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