کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3453450 1595915 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Alteration in oestrus cycle and implantation in Mus musculus administered aqueous wood ash extract of Azadirachta indica (neem)
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Alteration in oestrus cycle and implantation in Mus musculus administered aqueous wood ash extract of Azadirachta indica (neem)
چکیده انگلیسی

ObjectiveThe study was designed to investigate the alterations in oestrus cycle and implantation in Mus musculus administered aqueous wood ash extract of Azadirachta indica.MethodsMice were randomly grouped into four groups (5/group) where 0, 5, 50 and 100 mg/kg doses of the extract were orally administered for 20 d and microscopy of vaginal smear carried out daily to determine anti-ovulatory activity. Oestrus cycle, including metestrus, diestrus and oestrus phases and histopathology of uterus were examined. To assess abortifacient activity, pregnant mice were also administered extracts for 7 d and laparotomised on the 10th day of pregnancy to observe implantation in the horns of the uterus.ResultsDuration of metestrus and diestrus phases varied significantly, while the frequency at which the oestrus phase occurred was lowest at 100 mg/kg, (2.8 ± 0.2) and (1.2 ± 0.4) d, with degeneration of epithelial cells of glands in the uterus. Failure of implantation (0% implantation) was recorded in mice exposed to 50 and 100 mg/kg of the extract.ConclusionsAqueous wood ash extract of A. indica altered the duration of metestrus, diestrus and oestrus phases of the oestrus cycle and compromised implantation in female mice.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Asian Pacific Journal of Reproduction - Volume 5, Issue 3, May 2016, Pages 188–192
نویسندگان
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