Effects of caffeine on cell viability and activity of histone deacetylase 1Â and histone acetyltransferase in glioma cells

Our data suggest that a new strategy, caffeine, could increase glioma cell death by decreasing HDAC1 activity and/or by increasing p300 activity. The changes in HDAC1 and p300 activities appeared to occur earlier than loss of RT2 cells.