کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3908448 1599355 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hormonal receptor status, Ki-67 and HER2 expression: Prognostic value in the recurrence of ductal carcinoma in situ of the breast?
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Hormonal receptor status, Ki-67 and HER2 expression: Prognostic value in the recurrence of ductal carcinoma in situ of the breast?
چکیده انگلیسی


• High Ki-67 expression was independently associated with increased risk of recurrence in DCIS.
• High grade, administered treatment and younger age at diagnosis also correlated with recurrence risk.
• Recurrence rates were not associated with expression of ER, PR or HER2.

PurposeLocal recurrence is considered a major concern in patients diagnosed with ductal carcinoma in situ (DCIS), as its invasive occurrence is associated with high rates of distant disease and mortality. This study aims to assess the possible correlation of hormonal receptor status, Ki-67 and HER2 expression with recurrence rates in women with DCIS, taking also into account the potential prognostic effects of grade and age at diagnosis.Methods230 consecutive patients with DCIS were included in this study. Invasive and non-invasive recurrence events were recorded, as a total. Clinicopathological information, as well as PR positivity, ER positivity, HER2 positivity and ki-67 expression were analyzed. Multivariable Cox regression analysis was performed, examining the risk factors for recurrence.ResultsRecurrence was noted in 17.8% of cases; the median follow-up was 44 months. Higher grade (adjusted HR = 1.72, 95%CI: 1.06–2.78), age at diagnosis (adjusted HR = 0.60, 95%CI: 0.43–0.83), Ki-67 expression (adjusted HR = 1.78, 95%CI: 1.11–2.88), and type of administered treatment were independently associated with increased recurrence rates. Recurrence rates were not significantly associated with ER, PR status or HER2 expression.ConclusionIn addition to high grade, administered treatment and younger age at diagnosis, high Ki-67 expression seems to be independently associated with increased likelihood of recurrence in patients with DCIS. Future studies with additional molecular markers seem necessary to further improve the identification of high-risk patients for DCIS recurrence.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Breast - Volume 25, February 2016, Pages 57–61
نویسندگان
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