کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4111500 1605984 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Combination therapies using an intratympanic polymer gel delivery system in the guinea pig animal model: A safety study
ترجمه فارسی عنوان
درمان ترکیبی با استفاده از یک سیستم تحویل ژل پلی مرغی در مدل حیوانات دریایی: مطالعه ایمنی
کلمات کلیدی
ضد ویروسی، هیدروژل، اینترتیم پانک، دگزامتازون، سیدفوویر، گانچکلوویر
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری های گوش و جراحی پلاستیک صورت
چکیده انگلیسی

ObjectivesHigh dose antivirals have been shown to cause hearing loss when applied via the intratympanic route. The aim of this study was to determine if a combination therapy using dexamethasone (DXA) with either Cidofovir (CDV) or Ganciclovir (GCV), in solution or in PLGA-PEG-PLGA (PPP) hydrogel, is innocuous to the inner ear.MethodsCytomegalovirus (CMV)-free guinea pigs were separated into four principal study groups and treated via intratympanic injection (IT) of CDV/DXA solution, CDV/DXA Hydrogel, GCV/DXA solution and GCV/DXA hydrogel. Hearing thresholds were evaluated with pretreatment ABR and post injection weekly ABRs for a total follow up of 28 days. Temporal bone tissue was harvested and stained with Hematoxylin and Eosin for histologic analysis.ResultsABR analysis revealed that GCV/DXA in solution and in hydrogel led to a mild hearing loss at days 7–21 but returned to baseline by day 28 When administered via PPP hydrogel, CDV/DXA demonstrated mild persistent hearing loss at 32 kHz at 28 days. An inflammatory response was identified in the cochlear specimen of the CDV/DXA/PPP hydrogel group, in concert with mild hearing loss, at days 21 and 28.ConclusionResults of this study support the safe intratympanic use of higher concentrations of antivirals when combined with DXA, both in solution and when applied via PPP hydrogel.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pediatric Otorhinolaryngology - Volume 84, May 2016, Pages 132–136
نویسندگان
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