An Anterior-to-Posterior Shift in Midline Cortical Activity in Schizophrenia During Self-Reflection

Schizophrenia is associated with an anterior-to-posterior shift in introspection-related activation, as well as changes in functional connectivity, of the midline cortex. These findings provide support for the hypothesis that aberrant midline cortical function contributes to social cognitive impairment in schizophrenia.