کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4188600 | 1608289 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
El papel del placebo en ensayos clÃnicos en esquizofrenia
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
روانپزشکی و بهداشت روانی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In recent years, there appears to be a trend towards an increasing placebo response rate and decreasing signal detection of new treatments in clinical trials of antipsychotics in schizophrenia. This has been also observed in patients with major depressive disorder. Since the use of placebo in research remains the only valid formula to demonstrate the effectiveness of new treatments, despite the ethical aspects of the use of placebo, it is necessary to investigate what mechanisms influence this trend. The aim of this review is to find out why this trend is occurring and what can be done to counter it. For this purpose, we review relevant aspects in the design and development of clinical trials in schizophrenia. We will also propose new design models that may help to define the validity of the response rates of placebos, which are being implemented in recent years in clinical trials to demonstrate the efficacy of new treatments in patients with schizophrenia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: PsiquiatrÃa Biológica - Volume 20, Issue 4, OctoberâDecember 2013, Pages 63-69
Journal: PsiquiatrÃa Biológica - Volume 20, Issue 4, OctoberâDecember 2013, Pages 63-69
نویسندگان
Eduardo Jiménez Sola, Miquel Bernardo Arroyo,