کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4338997 1614896 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The moderating role of the dopamine transporter 1 gene on P50 sensory gating and its modulation by nicotine
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
The moderating role of the dopamine transporter 1 gene on P50 sensory gating and its modulation by nicotine
چکیده انگلیسی

Although schizophrenia has been considered primarily a disease of dopaminergic neurotransmission, the role of dopamine in auditory sensory gating deficits in this disorder and their amelioration by smoking/nicotine is unclear. Hypothesizing that individual differences in striatal dopamine levels may moderate auditory gating and its modulation by nicotine, this preliminary study used the mid-latency (P50) auditory event-related potential (ERP) to examine the single dose (6 mg) effects of nicotine (vs. placebo) gum on sensory gating in 24 healthy nonsmokers varying in the genetic expression of the dopamine transporter (DAT). Consistent with an inverted-U relationship between dopamine level and the drug effects, individuals carrying the 9R (lower gene expression) allele, which is related to greater striatal dopamine levels, tended to evidence increased baseline gating compared to 10R (higher gene expression) allele carriers and showed a reduction in gating with acute nicotine. The present results may help to understand the link between excessive smoking and sensory gating deficits in schizophrenia and to explain the potential functional implications of genetic disposition on nicotinic treatment in schizophrenia.

▶Inhibition of P50 is typically linked to 15q14 locus of the α7 nAChR gene. ▶P50 (and sensory gating) is also affected by human DAT1 gene. ▶There is increased suppression in the presence of the 9R allele of DAT1. ▶The 9R allele is associated with greater dopamine availability. ▶9R allele also modulates nicotine's effects on the P50 and sensory gating.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 180, 28 April 2011, Pages 148–156
نویسندگان
, , , , , ,