کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4407958 1618825 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Absorption and excretion of Tetrabromobisphenol A in male Wistar rats following subchronic dermal exposure
ترجمه فارسی عنوان
جذب و دفع تترابرموبیسفنول ای در سر موش صحرایی نر زیر تماس پوستی مزمن
کلمات کلیدی
تترابرموبیسفنول ای؛ جذب؛ دفع ادرار و مدفوع؛ قرار گرفتن در معرض پوست
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
چکیده انگلیسی


• TBBPA in serum, urine and feces after subchronic dermal exposure were determined.
• About 3.31–11.21% TBBPA was absorbed dermally under different dosing regimens.
• The majority of TBBPA was excreted in feces, but the minority in urine.

Tetrabromobisphenol A (TBBPA) is widely used as a flame retardant and frequently detected in environmental and biological samples. In this study, male Wistar rats were repeatedly exposed by dermal application to 20, 60, 200 and 600 mg TBBPA/kg body weight during 90 days. Concentrations of TBBPA in serum, urine and feces after dermal exposure were determined. TBBPA concentrations in serum ranged from 19.04 to 427.20 g/g lipids. The percentage of TBBPA dose recovered in serum on the 90th day varied from 0.002 ± 0.002% to 0.013 ± 0.008%, and the percentage of dose excreted in urine varied from 0.004 ± 0.002% to 0.072 ± 0.027%, while the percentage of dose recovered in feces were 3.30 ± 0.61% to 11.13 ± 3.16%. The results showed that about 3.31–11.21% TBBPA was absorbed dermally under different dosing regimens. TBBPA was excreted mainly in feces and small only amounts were recovered in urine.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 146, March 2016, Pages 189–194
نویسندگان
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