کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
4754526 1361463 2017 4 صفحه PDF ندارد دانلود کنید
عنوان انگلیسی مقاله
Retinal venous blood carbon monoxide response to bright light in male pigs: A preliminary study
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Retinal venous blood carbon monoxide response to bright light in male pigs: A preliminary study
چکیده انگلیسی

•11 male pig eyes were exposed to 80 min of 5000 lx bright white light.•Mean carbon monoxide levels in ophthalmic venous blood increased approximately 25%.•Acute bright light may raise carbon monoxide levels in ophthalmic venous blood.

The physical mechanism by which light is absorbed in the eye and has antidepressant and energizing effects in Seasonal Affective Disorder and other forms of psychiatric major depression is of scientific interest. This study was designed to explore one specific aspect of a proposed humoral phototransduction mechanism, namely that carbon monoxide (CO) levels increase in retinal venous blood in response to bright light. Eleven mature male pigs approximately six months of age were kept for 7 days in darkness and fasted for 12 h prior to surgery. Following mild sedation, anesthesia was induced. Silastic catheters were inserted into the dorsal nasal vein through the angular vein of the eye to reach the ophthalmic sinus, from which venous blood outflowing from the eye area was collected. The animals were exposed to 5000 lx of fluorescent-generated white light. CO levels in the blood were analyzed by gas chromatography before and after 80 min of light exposure. At baseline, mean CO levels in the retinal venous blood were 0.43 ± 0.05 (SE) nmol/ml. After bright light, mean CO levels increased to 0.54 ± 0.06 nmol/ml (two-tailed t-test p < 0.05). This study provides preliminary mammalian evidence that acute bright light exposure raises carbon monoxide levels in ophthalmic venous blood.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 168, March 2017, Pages 12-15
نویسندگان
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