کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
4765736 1423887 2018 8 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
Rational design of two-photon absorbing dicyanomethylene-4H-chromene derivatives and their application in bioimaging
ترجمه فارسی عنوان
طراحی منطقی از مشتقات dicyanomethylene-4H-chromene جذب دو فوتون و کاربرد آنها در نمایش تصویربرداری
کلمات کلیدی
مشتقات DCM؛ بزرگ استوکس تغییر؛ جذب دو فوتون؛ تصویربرداری بیولوژیک؛ حداقلات فلوئورسانس؛
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
چکیده انگلیسی


- A class of DCM derivatives with large 2PA cross-section at NIR range were synthesized.
- PCM was successfully applied for labelling cancer cells with minimal autofluorescence.
- PCM was successfully utilized to labelling zebrafish with deeper penetration (>300 μm).

In vitro and in vivo fluorescence imaging of cells and animals plays a significant role in studying biological systems. However, autofluorescence becomes a serious issue in vivo imaging under excitation at UV−vis wavelengths where biological molecules cause interference with the chromophore. In order to address this issue, a novel class of dicyanomethylene-4H-chromene (DCM) derivatives (PCM, PCV, BPCM and BPCV) that can be excited at ∼900 nm under two-photon excitation conditions and emit in the red wavelength region (≥600 nm) have been developed. Particularly, one of the DCM derivatives (PCM) shows several advantages, including remarkable two-photon absorption (2PA) properties in the near-infrared (NIR) region, superior photostability, large Stokes-shift and pronounced solvent-sensitive emission behavior, which is favorable for in vivo fluorescence labelling with a high signal-to-noise ratio.

A new DCM derivative (PCM) with remarkable two-photon absorption (2PA) properties was successfully applied for labelling cancer cells and zebrafish with minimal autofluorescence and deeper penetration (>300 μm).241

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Dyes and Pigments - Volume 148, January 2018, Pages 429-436
نویسندگان
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