Synthesis, characterization and antimicrobial activity of some new 4-(4-(2-isonicotinoylhydrazinyl)-6-((aryl)amino)-1,3,5-triazin-2-ylamino)-N-(pyrimidin-2-yl) benzenesulfonamides

In the present study, we have synthesized some novel 4-(4-(2-isonicotinoylhydrazinyl)-6-((aryl)amino)-1,3,5-triazin-2-ylamino)-N-(pyrimidin-2-yl)benzenesulfonamide derivatives (3a-v) and evaluated their in vitro antimicrobial activity against the representative panel of Gram-positive bacteria [Staphylococcus aureus (MTCC 96), Staphylococcus pyogenes (MTCC 442)], Gram-negative bacteria [Escherichia coli (MTCC 443), Pseudomonas aeruginosa (MTCC 1688)] and fungal strains [Candida albicans (MTCC 227), Aspergillus niger (MTCC 282), Aspergillus clavatus (MTCC 1323)]. Evaluation of antimicrobial activity revealed that compounds 3g, 3h, 3t, and 3v were the most active antibacterial, while compounds 3g, and 3h were the most potent antifungal agents. The structures of synthesized compounds (3a-v) were elucidated by IR, NMR spectroscopy and elemental analysis.