کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4929770 | 1432577 | 2017 | 5 صفحه PDF | دانلود رایگان |
- TNF-α, TNF-β, IFN-γ, IL-4 increase in First Episode Psychosis.
- IL-4 increase in Ultra High Risk state.
- No deviation in cortisol and IGF-1 in FEP and UHR states.
The aim of the study was to determine circulating cytokines, cortisol and Insulin-like Growth Factor (IGF)-1, known for their involvement in inflammation, in male patients with First Episode Psychosis (FEP) and subjects at Ultra High Risk (UHR) for Psychosis. The FEP group presented increased pro-inflammatory cytokines (TNF-α, IFN-γ, ΤNF-β) as well as increased anti-inflammatory cytokine (IL-4) compared with Healthy Controls (HC). The UHR group showed increased IL-4 against HC. In contrast, none of the groups did show deviation from normality in either cortisol or IGF-1 levels. These preliminary findings support the cytokines' role in the inflammatory hypothesis in psychosis.
Journal: Asian Journal of Psychiatry - Volume 26, April 2017, Pages 99-103