کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5031331 1470933 2018 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Molecular imprinting coupled with electrochemical analysis for plasma samples classification in acute myocardial infarction diagnostic
ترجمه فارسی عنوان
وارد کردن مولکولی همراه با تجزیه و تحلیل الکتروشیمیایی برای طبقه بندی نمونه های پلاسما در تشخیص انفارکتوس حاد قلب
کلمات کلیدی
پلیمرهای مونومر شده میوگلوبین، پلی (ارتو-فنیلینیدیامین)، الکترو پلیمریزاسیون، آزمایش خوشه ای، طبقه بندی نمونه پلاسما،
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


- Electroanalysis of Mb in plasma with SPEs modified with MWCNTs and Mb-imprinted film
- Plasma samples classification based on computational clustering of electrochemical data
- Discrimination between healthy donors and patients with acute myocardial infarction

Electroanalysis of myoglobin (Mb) in 10 plasma samples of healthy donors (HDs) and 14 plasma samples of patients with acute myocardial infarction (AMI) was carried out with screen-printed electrodes modified first with multi-walled carbon nanotubes (MWCNT) and then with a molecularly imprinted polymer film (MIP), viz., myoglobin-imprinted electropolymerized poly(o-phenylenediamine). The differential pulse voltammetry (DPV) parameters, such as a maximum amplitude of reduction peak current (A, nA), a reduction peak area (S, nA × V), and a peak potential (P, V), were measured for the MWCNT/MIP-sensors after their incubation with non-diluted plasma. The relevance of the multi-parameter electrochemical data for accurate discrimination between HDs and patients with AMI was assessed on the basis of electrochemical threshold values (this requires the reference standard method (RAMP® immunoassay)) or alternatively on the basis of the computational cluster assay (this does not require any reference standard method). The multi-parameter electrochemical analysis of biosamples combined with computational cluster assay was found to provide better accuracy in classification of plasma samples to the groups of HDs or AMI patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 99, 15 January 2018, Pages 216-222
نویسندگان
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