کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5031342 1470933 2018 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A multidimensional design of charge transfer interfaces via D-A-D linking fashion for electrophysiological sensing of neurotransmitters
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
A multidimensional design of charge transfer interfaces via D-A-D linking fashion for electrophysiological sensing of neurotransmitters
چکیده انگلیسی


- D-A structure biosensor is ultrasensitive due to amplification by the collective current signal.
- Bioaffinity recognition of phenothiazine-based assays.
- Future prospects to improve the biosensors are provided.

Donor-Acceptor (D-A) structure like host-guest pair serves as an organic charge-transfer (C-T) material with pregnant electrochemical and photochemical properties. Phenothiazine, a conjugated nitrogen-sulfur heterocyclic compound with broad pharmaceutical profile, is a strong electron donating system and applied in the synthesis of various classic antipsychotic drugs. In this proposal, a novel D-A molecule, 2,3-bis(4-(10H-phenothiazin-10-yl)phenyl)fumaronitrile (PTBFN), containig a diphenylfumaronitrile as the electrophilic central core and two phenothiazines as the peripheral electron donor functional groups is first designed and synthesized. Subsequently, the C-T layer based on the PTBFN polymer, poly(PTBFN), is obtained via a straightforward electrochemical method and used as an efficient electrocatalyst for dopamine (DA) detection. The logarithm of oxidation peak currents present an outstanding linear response to that of the DA concentration varying from 0.005 to 350 μM with a detection limit down to 0.70 nM, wherein the interferences of uric acid (UA) and ascorbic acid (AA) could be eliminated effectively. Moreover, the biosensor displays decent stability, excellent selectivity for different interfering compounds and applicability in real samples analysis. The favorable sensing performance suggests that the nontrivial D-A architecture is one of the promising bioaffinity catalysts for electrocatalysis and expected to provide wider application potential for biosensing construction and medical diagnostics.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 99, 15 January 2018, Pages 296-302
نویسندگان
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