کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5031344 1470933 2018 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lipopolysaccharides detection on a grating-coupled surface plasmon resonance smartphone biosensor
ترجمه فارسی عنوان
تشخیص لیپوپلی ساکارید بر روی یک سطح پلاسمون رزونانس بیوسنسور گوشی های هوشمند-گریتینگ همراه
کلمات کلیدی
رزونانس پلاسما سطحی؛ بیوسنسور؛ گوشی های هوشمند؛ گیرنده پپتید مصنوعی؛ لیپوپلی ساکارید
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


- A smartphone label-free biosensor based on grating-coupled SPR was developed.
- The sensor system relies on the smartphone's built-in flash light and camera.
- A synthetic peptide receptor was employed for the detection of LPS (endotoxins).

We report a smartphone label-free biosensor platform based on grating-coupled surface plasmon resonance (GC-SPR). The sensor system relies on the smartphone's built-in flash light source and camera, a disposable sensor chip with Au diffraction grating and a compact disk (CD) as the spectra dispersive unit. The Au grating sensor chip was modified with a synthetic peptide receptor and employed on the GC-SPR detection of lipopolysaccharides (known as endotoxins) with detection limit of 32.5 ng/mL in water. Upon incubation of various small and macro-molecules with the synthetic peptide modified sensor chips, we concluded the good selectivity of the sensor for LPS detection. In addition, the sensor shows feasibility for the detection of LPS in commonly used clinical injectable fluids, such as clinical-grade 0.9% sodium chloride intravenous infusion, compound sodium lactate intravenous infusion and insulin aspart. The developed sensor platform offers the advantage of portability and simplicity, which is attractive for point-of-care and remote detection of biomedical and environmental targets.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 99, 15 January 2018, Pages 312-317
نویسندگان
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