کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5032685 | 1471129 | 2017 | 9 صفحه PDF | دانلود رایگان |
- Machine learning approach enables accurate detection of bursts in preterm EEG.
- Features of amplitude and spectral shape capture discriminating information.
- Improves reliability of estimates of inter-burst intervals.
Aim: To develop a method that segments preterm EEG into bursts and inter-bursts by extracting and combining multiple EEG features. Methods: Two EEG experts annotated bursts in individual EEG channels for 36 preterm infants with gestational age < 30 weeks. The feature set included spectral, amplitude, and frequency-weighted energy features. Using a consensus annotation, feature selection removed redundant features and a support vector machine combined features. Area under the receiver operator characteristic (AUC) and Cohen's kappa (κ) evaluated performance within a cross-validation procedure. Results: The proposed channel-independent method improves AUC by 4-5% over existing methods (p < 0.001, n=36), with median (95% confidence interval) AUC of 0.989 (0.973-0.997) and sensitivity-specificity of 95.8-94.4%. Agreement rates between the detector and experts' annotations, κ=0.72 (0.36-0.83) and κ=0.65 (0.32-0.81), are comparable to inter-rater agreement, κ=0.60 (0.21-0.74). Conclusions: Automating the visual identification of bursts in preterm EEG is achievable with a high level of accuracy. Multiple features, combined using a data-driven approach, improves on existing single-feature methods.
Journal: Medical Engineering & Physics - Volume 45, July 2017, Pages 42-50