کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
504777 864429 2016 5 صفحه PDF ندارد دانلود رایگان
عنوان انگلیسی مقاله
Cancerome: A hidden informative subnetwork of the diseasome
ترجمه فارسی عنوان
Cancerome: یک زیرشبکه آموزنده پنهان diseasome
کلمات کلیدی
Cancerome؛ Diseasome؛ شبکه یکپارچه بیماری های انسانی ؛ شبکه های بیماری بیماری ؛ شبکه شباهت بیماری
Cancerome; Diseasome; Integrated human disease network; Disease–disease network; Disease similarity network
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر نرم افزارهای علوم کامپیوتر
چکیده انگلیسی


• Node in disease–disease network is a disease and edge explain similarity.
• We constructed an integrated disease network using different features of diseases.
• We extracted a cancer-related subnetwork of IHDN, named cancerome.
• For reach a useful network we need consider all features of a biological systems.

Neoplastic disorders are a leading cause of mortality and morbidity worldwide. Studying the relationships between different cancers using high throughput-generated data may elucidate undisclosed aspects of cancer etiology, diagnosis, and treatment. Several studies have described relationships between different diseases based on genes, proteins, pathways, gene ontology, comorbidity, symptoms, and other features. In this study, we first constructed an integrated human disease network based on nine different biological aspects, including molecular, functional, and clinical features. Next, we extracted the cancerome as a cancer-related subnetwork. Further investigation of cancerome could reveal hidden mechanisms of cancer and could be useful in developing new diagnostic tests and effective new drugs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computers in Biology and Medicine - Volume 76, 1 September 2016, Pages 173–177
نویسندگان
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