کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5121963 1486846 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A threshold analysis assessed the credibility of conclusions from network meta-analysis
ترجمه فارسی عنوان
تجزیه و تحلیل آستانه اعتبار نتیجه گیری از متا آنالیز شبکه را ارزیابی کرد
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی سیاست های بهداشت و سلامت عمومی
چکیده انگلیسی

ObjectiveTo assess the reliability of treatment recommendations based on network meta-analysis (NMA).Study Design and SettingWe consider evidence in an NMA to be potentially biased. Taking each pairwise contrast in turn, we use a structured series of threshold analyses to ask: (1) “How large would the bias in this evidence base have to be before it changed our decision?” and (2) “If the decision changed, what is the new recommendation?” We illustrate the method via two NMAs in which a Grading of Recommendations Assessment, Development and Evaluation (GRADE) assessment for NMAs has been implemented: weight loss and osteoporosis.ResultsFour of the weight-loss NMA estimates were assessed as “low” and six as “moderate” quality by GRADE; for osteoporosis, six were “low,” nine were “moderate,” and 1 was “high.” The threshold analysis suggests plausible bias in 3 of 10 estimates in the weight-loss network could have changed the treatment recommendation. For osteoporosis, plausible bias in 6 of 16 estimates could change the recommendation. There was no relation between plausible bias changing a treatment recommendation and the original GRADE assessments.ConclusionsReliability judgments on individual NMA contrasts do not help decision makers understand whether a treatment recommendation is reliable. Threshold analysis reveals whether the final recommendation is robust against plausible degrees of bias in the data.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Epidemiology - Volume 80, December 2016, Pages 68-76
نویسندگان
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