1-Chlorobenzotriazole assisted oxidative cleavage and kinetic study of vitamin B1 in presence of homogeneous catalyst ruthenium Chloride: A mechanistic pathway

In the present investigation, using micro concentration of ruthenium (III) as a homogenous catalyst, the oxidative cleavage of vitamin B1 or thiamine (THM) by novel oxidant 1-chlorobenzotriazole(CBT) and its mechanistic pathway were studied. Such studies are greatly helpful in gaining an insight into the interaction of metal ions with THM in redox reactions. The reaction follows a pseudo-first-order rate throughout the variation of CBT. It was observed to be fractional order with respect to [THM] and [Ru(III)] catalyst and inverse first order with respect to [H+]. The investigators, thus, concluded that the variations of reduced product benzotriazole(BTA) and halide ions retarded the reaction rate and it shows inverse fractional order on each.

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