کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5137162 | 1494534 | 2017 | 8 صفحه PDF | دانلود رایگان |
- Dietary EPA-PL was superior to DHA-PL on reducing atherosclerosis via distinct pathway.
- EPA-PL significantly reduced serum cholesterol level, while DHA-PL was ineffective.
- DHA-PL was superior to EPA-PL in suppressing arotic inflammatory.
Dietary fish oil could prevent and treat atherosclerosis by improving lipid metabolism; in apolipoprotein E-deficient (apoEâ/â) mice, it was ineffective at lowering serum lipid levels but still showed anti-atherosclerosis action. To date, no direct evidence has comparatively evaluated the effect of docosahexaenoic acid-enriched and eicosapentaenoic acid-enriched phospholipids (DHA-PL and EPA-PL) on atherosclerosis in apoEâ/â mice. The present study suggested that both 1% dietary DHA-PL and EPA-PL could significantly reduce atherosclerotic lesions (37.4% and 53.4%, respectively) in high fat diet apoEâ/â mice. EPA-PL significantly decreased serum and hepatic lipid levels, by mediating mRNA and protein levels of genes related to hepatic cholesterol metabolism, whereas DHA-PL was ineffective. In the suppression of aortic proinflammatory cytokines, DHA-PL was superior to EPA-PL at reducing TNF-α, IL-6, and IL-1β transcription. In conclusion, the action of DHA-PL was simply anti-inflammatory, and that of EPA-PL was mainly the improvement of lipid metabolism in the amelioration of atherosclerosis.
Journal: Journal of Functional Foods - Volume 32, May 2017, Pages 90-97