کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5137517 | 1494538 | 2017 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ferulic acid-mediated protection against neomycin-induced hair cell loss in transgenic zebrafish
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کلمات کلیدی
DPFGFPhpfROS - ROSTUNEL - تونلdays post-fertilization - روز پس از لقاحhours post-fertilization - ساعت پس از لقاحOtotoxicity - سمیت زایی برای گوش، اتوتوکسیسیتیFerulic acid - فرولیک اسیدTransgenic zebrafish - ماهی قزل آلا ترانس ژنیکNeomycin - نومیدینgreen fluorescent protein - پروتئین فلورسنت سبزReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Ferulic acid (FA) derivatives have applied in American clinical trials for preventing and treating auditory dysfunctions. However, the effects of FA on neomycin-mediated sensorineural hearing loss are still unknown. We developed a transgenic zebrafish (pvalb3b:TagGFP) expressing green-colored hair cells in the inner ear and lateral line neuromasts by Tol2 system. Then, we determined the effects of FA on neomycin-induced ototoxicity in 4 dpf transgenic larvae. FA conferred significant protection against hair cell loss across a wide range of neomycin concentrations. In addition, FA significantly decreased intracellular ROS production and TUNAL reactions in larvae pretreated with FA prior to neomycin exposure. These findings suggest that FA has antioxidant effects and can attenuate neomycin-induced hair cell death in neuromasts. The green hair cells of transgenic zebrafish lateral line may provide a useful basis on which to investigate the cellular pathways related to the hair cell death and survival imparted by FA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 28, January 2017, Pages 157-167
Journal: Journal of Functional Foods - Volume 28, January 2017, Pages 157-167
نویسندگان
Ju Chang-Chien, Yung-Chang Yen, Shuan-Yow Li, Tsai-Ching Hsu, Jiann-Jou Yang,