کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5137562 1494530 2017 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Urtica thunbergiana prevents UVB-induced premature skin aging by regulating the transcription factor NFATc1: An in vitro and in vivo study
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Urtica thunbergiana prevents UVB-induced premature skin aging by regulating the transcription factor NFATc1: An in vitro and in vivo study
چکیده انگلیسی

Exposure to UV radiation is the primary cause of skin photoaging. UV damage is a result of increases in MMPs activity and degradation of collagen, resulting in wrinkle formation. Although the antioxidant potential of Urtica species is well known, the protective effects of Urtica thunbergiana against UVB-irradiated photoaging have not been explored. To examine the anti-photoaging effects of Urtica thunbergiana leaf extract (UT), levels of intracellular ROS, MMPs, IL-6, procollagen type 1, and TGF-β1 were investigated in UVB-irradiated NHDFs. We also examined anti-wrinkle effects of UT by measuring physiological and histological skin changes in hairless mice. Our data showed that UVB exposure decreased the level of phosphorylated NFATc1. One active component of UT, chlorogenic acid (CGA), regulated NFATc1 dephosphorylation to a similar extent as tacrolimus, a calcineurin inhibitor. Our results suggest that UT and its active component, CGA, have the potential to prevent UVB-induced premature skin aging by regulating NFATc1.

130

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 36, September 2017, Pages 162-177
نویسندگان
, , , , , , ,