Sesquiterpenoids from Curcuma wenyujin dreg and their biological activities

Four new sesquiterpenoids, 4,8-dioxo-6β-hydroxyl-7β,11-epoxycarabrane (1), 4,8-dioxo-6β-hydroxyl-7α,11-epoxycarabrane (2), wenyujinins Q and R (3-4), and nine known sesquiterpenoids (5-13) were isolated from the Curcuma wenyujin dreg. Compounds 3, 5-8 exhibited strong broad-spectrum antifungal activities against tested nine pathogenic fungi.