کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5143309 1496474 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Metal homeostasis in infectious disease: recent advances in bacterial metallophores and the human metal-withholding response
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Metal homeostasis in infectious disease: recent advances in bacterial metallophores and the human metal-withholding response
چکیده انگلیسی
A tug-of-war between the mammalian host and bacterial pathogen for nutrients, including first-row transition metals (e.g. Mn, Fe, Zn), occurs during infection. Here we present recent advances about three metal-chelating metabolites that bacterial pathogens deploy when invading the host: staphylopine, staphyloferrin B, and enterobactin. These highlights provide new insights into the mechanisms of bacterial metal acquisition and regulation, as well as the contributions of host-defense proteins during the human innate immune response. The studies also underscore that the chemical composition of the microenvironment at an infection site can influence bacterial pathogenesis and the innate immune system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Chemical Biology - Volume 37, April 2017, Pages 10-18
نویسندگان
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