کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5144642 | 1496867 | 2017 | 35 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Multi-stimuli responsive smart chitosan-based microcapsules for targeted drug delivery and triggered drug release
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In the present study, we designed a novel, multi-stimuli responsive, biocompatible and non-immunogenic smart carrier for targeted delivery and triggered release of hydrophobic drugs. The designed multi-stimuli responsive smart chitosan-based microcapsules (MSRS-CS-MCs) have been fabricated successfully from folic acid (FA) functionalized thiolated chitosan via a facile sonochemical method. Targeting moiety FA and red fluorescent dye (Rhodamine B isothiocyanate, RITC) were immobilized onto the shells of microcapsules. Meanwhile, oleic acid (OA) modified Fe3O4 magnetic nanoparticles (OA-Fe3O4Â MNPs) and a model hydrophobic drug, green fluorescent dye (Coumarin 6, C6), were encapsulated into the microcapsules. As drug carriers, the obtained spherical MSRS-CS-MCs with the average size of 500Â nm showed excellent magnetic responsive ability, favorable selectively folate-receptor-mediated targeting functionality to the HeLa cells, and attractive reduction-responsive release ability for hydrophobic drugs. The integration of magnetic and reduction dual-responsiveness, folate-receptor-mediated targeting functionality and fluorescence visualization into the versatile microcapsules make MSRS-CS-MCs promising nanocarriers for future biomedical applications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasonics Sonochemistry - Volume 38, September 2017, Pages 145-153
Journal: Ultrasonics Sonochemistry - Volume 38, September 2017, Pages 145-153
نویسندگان
Xuejun Cui, Xinyu Guan, Shuangling Zhong, Jie Chen, Houjuan Zhu, Zhanfeng Li, Fengzhi Xu, Peng Chen, Hongyan Wang,