Design, synthesis and evaluation of anticancer activity of ruthenium (II) polypyridyl complexes

Four Ru(II) complexes [Ru(NN)2(PFPIP)]2 + (PFPIP = 2-(2,3,4,5,6-pentafluorophenyl)[4,5-f]imadazo [1,10]phenanthroline) were synthesized and characterized. The in vitro cytotoxicity, apoptosis, cellular uptake, comet assay, cell invasion, autophagy, reactive oxygen species (ROS), mitochondrial membrane potential, cell cycle arrest and western blot analysis were investigated.170