A comparison study on RNase A oligomerization induced by cisplatin, carboplatin and oxaliplatin

The oligomerization process of bovine pancreatic ribonuclease in the presence of cisplatin, carboplatin and oxaliplatin is compared. X-ray structures of the monomeric protein adducts formed with the three drugs explain the different effects exerted by the three drugs on enzymatic activity and protein aggregation.59