Recent metal-catalysed asymmetric hydroaminations of alkenes

The selective and asymmetric addition of amines across alkene C=C bonds (hydroamination of alkenes) is one of the most important tool to synthesise chiral amines. Though this reaction remains a challenge due to its high energy gap and the difficult control of the enantioselection, some chiral organometallic catalysts can provide promising activities and enantioselectivities.185